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人成纤维细胞样滑膜细胞:骨关节炎:HFLS-OA

更新日期:2014年03月21日 浏览次数:
名称:人成纤维细胞样滑膜细胞:骨关节炎:HFLS-OA

货号:408OA-05a

英文名称:Human Fibroblast-Like Synoviocytes: Osteoarthritis: HFLS-OA

规格: vial

价格: 11219.0RMB

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Human Fibroblast-Like Synoviocytes: Osteoarthritis (HFLS-OA) provide an excellent cellular model for studying synoviocyte physiology in relation to development and treatment of osteoarthritis.
HFLS-OA from Cell Applications, Inc. have been shown to:
  • Possess osteogenic, chondrogenic and adipogenic potentials
  • Express about half of the mesenchymal stem cell related transcription factors and molecular markers identified in a comprehensive study
  • Involve LPA–EDG2 signaling in the pathogenesis of osteoarthritis via catabolic processes
  • Employ parvorvirus B19 capsid proteins to activate synoviocyte migration and induction of the inflammatory response leading to acute symmetrical polyarthropathy
Finally, all three types of HFLS (normal, RA and OA), all from Cell Applications, Inc. were used to investigate the role of human endogenous retroviruses (HERVs) in development of rheumatoid arthritis, and suggest that activated expression of different forms of HERV contribute to development of rheumatoid arthritis symptoms by different mechanisms.

 

Tissue
Human synovial tissue from donor with osteoarthrits
QC
No bacteria, yeast, fungi, mycoplasma, virus
Cryovial
500,000 HFLS-OA (2nd passage) frozen in Basal Medium w/ 10% FBS, 10% DMSO
Kit
Croyvial frozen HFLS-OA (408OA-05a), Gr Med (415-500), Subcltr Rgnt Kit (090K)
Proliferating
Shipped in Gr Med, 3rd psg (flasks or plates)
Doublings
At least 5
Applications
Laboratory research use only (RUO). Not for human, clinical, diagnostic or veterinary use.

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